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KMID : 0545120050150010216
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Journal of Microbiology and Biotechnology
2005 Volume.15 No. 1 p.216 ~ p.220
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Biological Characterization of Periconicins, Bioactive Secondary Metabolites, Produced by Periconia sp. OBW-15
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Shin DS
Oh MN/Yang HC/Oh KB
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Abstract
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Periconicin A and B two new fusicoccane diterpenes originally isolated from the cultures of endophytic fungus Periconia sp. OBW-15 were tested by several biological assays. Periconicin A was consistently more active than periconicin B. In an antifungal activity assay periconicin A showed potent inhibitory activity against the agents of human mycoses including Candida albicans Trichophyton mentagrophytes and T. rubrum with minimum inhibitory concentration (MIC) in the range of 3.12- 6.25 μg/ml. In a plant growth regulatory activity assay periconicins inhibited hypocotyl elongation and root growth of Brassica campestris L. and Raphanus sativus L. At concentrations below 1 μg/ml however both compounds accelerated root growth by 110- 135%. From these results it is apparent that a methyl group positioned in a cyclopentane ring may play an important role in plant and fungal growth inhibitory activity.
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